| 目录号 | MZ0701-10MG | 售价 | 518.00元 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 规格 | 10mg | 运输温度 | 室温运输 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 其他名称 | Flagecidin; Wuningmeisu C; NSC76712; AI350846; 回香霉素； | 保存温度 | 2-8ºC干燥保存，或置于-20ºC长期干燥保存！ | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CAS号 | 22862-76-6 | 有效期 | 2年 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 应用 | 抗生素；JNK激活剂 | 订购数量 |
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产品简介: Anisomycin 茴香霉素
搜索关键词： Anisomycin茴香霉素；Flagecidin；Protein synthesis inhibitor蛋白合成抑制剂；JNK activator JNK激活剂；SP600125；CAS NO：22862-76-6；
产品订购：更大包装或产品技术问题，请来电/在线咨询，电话：021-54736159 。
产品描述： 茴香霉素（Anisomycin），来源于灰色链霉菌（Streptomyces griseolus）的吡咯烷抗生素，是一种有效的蛋白合成抑制剂，通过抑制真核生物核糖体的肽酰转移酶活性来发挥作用。据报道能诱导许多细胞的凋亡发生，包括早幼粒细胞白血病细胞、Jurkat细胞、心室肌细胞和结肠腺癌细胞。启动胞内信号和立早基因诱导。 茴香霉素是强效的JNK激活剂，活化MAP激酶（JNK/SAPK和p38/RK）。作为一种有效的信号通路激动剂，选择性引发即刻早期基因诱导的同源性脱敏（c-fos，fosB，c-jun，junB和junD）。茴香霉素（30mg/kg）表现出优于环孢霉素A（MZ2501-10MG）的免疫抑制活性，阻断皮肤移植小鼠的T细胞增殖。
产品特性
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浓度 |
1mg |
5 mg |
10mg |
|
1mM |
3.7693 mL |
18.8466 mL |
37.6932 mL |
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5mM |
0.7539mL |
3.7693 mL |
7.5386 mL |
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10mM |
0.3769 mL |
1.8847 mL |
3.7693 mL |
|
50mM |
0.0754 mL |
0.3769 mL |
0.7539mL |
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文献1，Yan J et al. c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias. Cardiovasc Res. 2013 Mar 1;97(3):589-97. PMID: 23241357 体外研究（细胞实验）： 细胞类型（Cell types）：Mouse atrial myocyte line (HL-1) 实验方法（Assay）：Atrial myocytes were treated with 50 ng/mL anisomycin with or without 2 µmol/L SP600125, or a corresponding amount of the DMSO solvent for 16 or 24 h followed by biochemical or optical mapping studies. 体内研究（动物模型）： 动物模型（Animal Model）：Young (6 months) and aged (54 months) male New Zealand White rabbits 实验方法（Assay）：LA effective refractory period (AERP) was measured using an S1-S2 pacing protocol and atrial arrhythmias (AT/AF) were induced using burst pacing in open-chest heartsin young rabbits with (n = 4) or without (n = 5)anisomycin treatment (15 mg/kg, iv, four treatments over 9 days)and aged rabbits without anisomycin treatment (n = 6). |
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文献2，Lattal KM et al. Behavioral impairments caused by injections of the protein synthesis inhibitor anisomycin after contextual retrieval reverse with time. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4667-72. PMID: 15070775 体内研究（动物模型）： 动物模型（Animal Model）：Male C57BL/6 mice (8-12 weeks old) 配制方法（Formulation）：Anisomycin wasdiluted in salineand dissolved in 1 M HCl. The pH was adjusted to≈7 with 1 M NaOH. 实验方法（Assay）：Mice received subcutaneous injections of 50 or 75 mg of anisomycin/kg of body weight or an equivalent volume of saline in the first experiment. Injections in all other experiments were 50 mg/kg of anisomycin or an equivalent volume of saline. |
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文献3，Guo Xet al. GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway. Elife. 2016 Mar 14;5:e11903.PMID: 26974342. 体内研究（动物模型）： 动物模型（Animal Model）： 配制方法（Formulation）：Anisomycin was dissolved inDMSO to prepare a stock solution anddiluted inPBS before each administration. 实验方法（Assay）：Anisomycin (30 mg/kg body weight)or vehicle was injected subcutaneously daily after optic nerve crush. To inhibit OPP incorporation, anisomycin (50 μg/ml) was injected intravitreally 1 hr before and together with OPP administration. |
相关产品：更大包装或产品技术问题，请来电/在线咨询，电话：021-54736159 。
|
货号 |
产品名称 |
规格 |
|
MZ0701-5MG |
Anisomycin 茴香霉素 |
5mg |
|
MZ0702-10MG |
SP600125 JNK抑制剂 |
10mg |
|
MZ0201-10MG |
Rapamycin (Sirolimus) 雷帕霉素（西罗莫司） |
10mg |
|
MZ2501-10MG |
Cyclosporin A (CsA) 环孢霉素A |
10mg |
注意事项
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— —Written/Edited by V. Shallan【版权归MKBio懋康所有】
上海懋康生物科技有限公司是一家涉足于生命科学和生物技术领域研究的试剂、仪器和实验室消耗品与实验服务工作，主要从事细胞生物学、植物学、分子生物学、免疫学、生物化学、蛋白组学。生物制药与诊断试剂研发生产等领域。 本公司秉承“以人为本，以诚为信、合同守信”的经营理念。坚持"品质保障"的原则为广大客户提供优质产品。
