产品简介:
Ac-DEVD-CHO (Caspase-3/7 inhibitor)
凋亡相关蛋白Caspase-3/7抑制剂
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产品标签
Ac-DEVD-CHO;Z-DEVD-FMK;Z-VAD-FMK;Caspase-3 inhibitor;细胞凋亡抑制剂;CCCP;CAS: 184179-08-6;CAS:169332-60-9;
产品信息
产品名称
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产品编号
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规格
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价格(元)
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Ac-DEVD-CHO (Caspase-3/7 inhibitor)凋亡相关蛋白Caspase-3/7抑制剂
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MX3273-1MG
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1mg
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1280
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MX3273-5MG
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5mg
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3680
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产品描述
Ac-DEVD-CHO是一种合成四肽,是II类caspases-caspase-3/7的有效抑制剂,Kis分别是0.23和1.6nM。常用来抑制凋亡细胞内的caspase-3/7活性,以及研究caspase-3/7活化后的下游事件。另外,Ac-DEVD-CHO还能抑制其他caspases,对caspases-1/-2/-4/-5/-6/-8/-9和-10的Kis分别是18、1710、132、205、31、0.92、60和12 nM[1]。
产品特性
1) CAS NO.:169332-60-9
2) 化学名:N-acetyl-L-α-aspartyl-L-α-glutamyl-N-(2-carboxyl-1-formylethyl)-L-valinamide
3) 同义名:N-Ac-Asp-Glu-Val-Asp-CHO; Caspase-3 Inhibitor I;
4) 序列:N-Acetyl-Asp-Glu-Val-Asp-al
5) 分子式:C20H30N4O11
6) 分子量:502.47 g/mol
7) 纯度:≥98%
8) 溶解性:溶于DMSO(~25mg/ml)、乙醇(~30mg/ml)、H2O(10mg/ml)
保存与运输方法
保存:-20℃干燥保存,至少1年稳定。
运输:冰袋运输。
注意事项
1)第一次溶解粉末配制储存液时,请根据单次使用次数分装冻存,一定要避免反复冻融,以保证产品的活性不受影响。
2)-20℃冻存的储存液从冰箱取出后,可在25℃水浴锅温育片刻直到全部融解,离心后待用。
3)本品仅用作科研用途,不得用作临床诊断或治疗,不得用于食品或药品,绝对禁止用在人身上。
4)为了您的安全和健康,请穿实验服并戴一次性手套操作。
储存液配制
质量
溶剂体积
浓度
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1mg
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5mg
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10mg
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1mM
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1.9902 mL
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9.9508 mL
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19.9017 mL
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5mM
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0.3980 mL
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1.9902 mL
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3.9803 mL
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10mM
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0.1990 mL
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0.9951 mL
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1.9902 mL
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使用方法【源自文献,仅作参考】
文献1,He LG et al. Sinomenine induces apoptosis in RAW 264.7 cell-derived osteoclasts in vitro via caspase-3 activation. Acta Pharmacol Sin. 2014 Feb;35(2):203-10.PMID: 24362325
体外研究(细胞实验):
细胞类型(Cell type):Osteoclast-like cells (OCLs)
实验方法(Assay):OCLs were incubated with RANKL followed by different concentrations of SIN (0.5 and 1 mmol/L) or camptothecin (4 μmol/L) with or without Ac-DEVD-CHO (10 μmol/L)for 24 h. Camptothecin was used as a positive control to induce apoptosis. Caspase-3 activity in the cells was measured using the caspase-3 colorimetric activity assay kit.
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文献2,Katai N et al. Apoptotic retinal neuronal death by ischemia-reperfusion is executed by two distinct caspase family proteases. Invest Ophthalmol Vis Sci. 1999 Oct;40(11):2697-705. PMID: 10509668
体内研究(动物模型):
动物模型(Animal Model):Ischemia Model of Male Sprague–Dawley rats weighing 250 to 300 g
实验方法(Assay):A 20mM solution of Ac-YVAD-CHO and Ac-DEVD-CHO in DMSO was prepared, and 2 μl of the solution was injected into the vitreous cavity with a 30-gauge needle 24 hours before ischemic insult.Another 3 μl was injected into the vitreous at the time of reperfusion. As a control, DMSO (vehicle) was injected in the same way. Twenty-four hours after reperfusion, eyes were enucleated, and TUNEL staining was performed.
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— —Written/Edited by V. Shallan【版权归MKBio懋康所有】
上海懋康生物科技有限公司是一家涉足于生命科学和生物技术领域研究的试剂、仪器和实验室消耗品与实验服务工作,主要从事细胞生物学、植物学、分子生物学、免疫学、生物化学、蛋白组学。生物制药与诊断试剂研发生产等领域。 本公司秉承“以人为本,以诚为信、合同守信”的经营理念。坚持"品质保障"的原则为广大客户提供优质产品。
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