目录号 | MS0043-5G | 售价 | 198.00元 | |||||||||||||||||||||||||||||||||||||||||||
规格 | 5g | 运输温度 | 室温运输 | |||||||||||||||||||||||||||||||||||||||||||
其他名称 | NSC-163039, ICN-1229, RTCA, Tribavirin, Ribasphere, Rebetol, Virazole, Copegus; | 保存温度 | 室温干燥保存,可置于-20°C长期干燥保存 | |||||||||||||||||||||||||||||||||||||||||||
CAS号 | 36791-04-5 | 有效期 | 3年 | |||||||||||||||||||||||||||||||||||||||||||
应用 | 抗病毒剂 | 订购数量 |
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产品简介: Ribavirin 利巴韦林(病毒唑) 产品关键词: Ribavirin 利巴韦林;Virazole 病毒唑;Ribavirin 5′-phosphate 利巴韦林5’-磷酸;Antiviral agent 抗病毒剂;肌苷单磷酸(IMP)脱氢酶;CAS:36791-04-5;
产品信息
【温馨提示】:见我司(MKBio)的小分子化合物常见问题-懋康生物。
产品描述 产品描述 利巴韦林(Ribavirin),俗称病毒唑,一种具广谱抗病毒特性的鸟苷类似物,靶向包括呼吸道合胞病毒(RSV)、丙型肝炎病毒(HCV)和流感病毒在内的DNA和RNA病毒。利巴韦林是一种药物前体,能够被细胞内激酶单磷酸或三磷酸化而激活。这些磷酸化衍生物对细胞和病毒内的酶产生各种效应,引起病毒复制的抑制。利巴韦林结合并重新分布哺乳动物eIF4E从细胞核到细胞质(Ki~ 0.3 μM,利巴韦林三磷酸,活性代谢物)。能够抑制原代AML-M5祖细胞的克隆形成(IC50~1 μM),还能减缓急性髓细胞性白血病(AML)的疾病严重程度。
产品特性 1) CAS NO:36791-04-5 2) 化学名:1-β-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide 1-β-D-呋喃核糖-1,2,4-三氮唑-3-羟酰胺 3) 英文同义名:NSC-163039, ICN-1229, RTCA, Tribavirin, Ribasphere, Rebetol, Virazole, Copegus; 4) 中文同义名:病毒唑,三氮唑核苷,三唑核苷; 5) 分子式:C8H12N4O5 6) 分子量:244.21 g/mol 7) 外观:白色或类白色结晶性粉末 8) 纯度:>99% 9) 溶解性:溶于水(≥20mg/ml),DMSO(≥20mg/ml),不溶于乙醇、乙醚、二氯甲烷 10)化学结构式:
保存与运输方法 保存:室温干燥保存,可置于-20°C长期干燥保存,3年有效。 运输:室温运输。
注意事项 1) 关于化合物溶解说明:化合物溶解性比如≥20mg/ml,说明至少有20mg/ml的溶解度,但不确定最大饱和溶解度。化合物的溶解度会因生产厂家和批次不同产生差异,具体以实际测试为准。 2) 本品并非商业化药物,仅限科研用途,不可用于临床或诊疗用途。 3) 为了您的安全和健康,请穿实验服并戴一次性手套操作。
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文献1,Chang J et al. Combination of alpha-glucosidase inhibitor and ribavirin for the treatment of Dengue virus infection in vitro and in vivo. Antiviral Res. 2011 Jan;89(1):26-34. PMID: 21073903 体内研究: 动物模型(Animal Model):DENV (serotype 2, TSV01 strain) infected mice 给药剂量(Dosages):The mice were challenged with DENV (serotype 2, TSV01 strain), at 5×106pfu/mouse via i.p. injection. Imino sugar (CM-10-18) was given orally at 75mg/kg twice daily at 12 hr intervals, andribavirin was given orally at 40mg/kg once daily, for 3 consecutive days post-infection. PBS was given to control mice.Blood samples were drawn 3 days post-infection for determination of plasma virus titer by plaque assay. 实验结果(Results):While ribavirin at 40mg/kg by itself did not reduce viremia, and 75 mg/kg of CM-10-18 treatment only modestly reduced the viremia by 1.9-fold, combination of the two compounds reduced the viremia by 4.7-fold. |
文献2,Kentsis A et al. Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap. Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18105-10. PMID: 15601771 体内研究: 动物模型(Animal Model):Female 5- to 7-week old athymic NCr-nu/nu mice 药物配制(Preparation):For treatments, drugs were dissolved in PBS (pH 7.4) and filter-sterilized. Untreated cells and animals received filter-sterilized PBS. 给药剂量(Dosages):Nude mice were engrafted by using sub-cutaneous injection of eIF4E-dependent FaDu cells andtreated with 40 μg/kg ribavirin orally each day, yielding a mean body concentration of ≈1 μM.Photograph of tumors resectedafter 20 days of treatment. 实验结果(Results):After 20 days of ribavirin treatment, mean tumor volume of animals in the treatment group was 6-fold less than those in the untreated control group. At this low concentration, ribavirin was apparently well tolerated and minimally toxic as suggested by the absence of treatment-associated mortality and of effect on body weight. |
— —Written/Edited by V. Shallan【版权归MKBio懋康所有】
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