目录号 | MZ7351-10MG | 售价 | 5980.00元 | ||||||||||||||||||||||||||||||||||||||||||
规格 | 10mg | 运输温度 | 冰袋运输 | ||||||||||||||||||||||||||||||||||||||||||
其他名称 | Victoza, Liraglutida, Liraglutidum, NN 2211, NN-2211 | 保存温度 | -20℃避光干燥保存 | ||||||||||||||||||||||||||||||||||||||||||
CAS号 | 204656-20-2 | 有效期 | 至少2年有效 | ||||||||||||||||||||||||||||||||||||||||||
应用 | 胰高血糖素样肽-1(GLP-1)受体激动剂 | 订购数量 |
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产品简介: Liraglutide 利拉鲁肽
Liraglutide 利拉鲁肽; GLP-1受体激动剂;Metformin HCl 盐酸二甲双胍;Acarbose 阿卡波糖;Antidiabetic drug抗糖尿病药物;Streptozotocin (STZ) 链脲佐菌素;CAS:204656-20-2;
产品信息
【温馨提示】:见我司(MKBio)的小分子化合物常见问题-懋康生物。 【温馨提示】:见我司(MKBio)整理的糖尿病模型建立-链脲佐菌素(STZ)。
产品描述 利拉鲁肽(Liraglutide)是一种长效的胰高血糖素样肽-1(GLP-1)受体激动剂,是GLP-1 (7-37)的合成衍生物含有一个棕榈酸基团[1]。表达人GLP-1受体的CHO细胞内利拉鲁肽能够提高cAMP累积(EC50=61 pM)。体外原代新生大鼠胰岛β-细胞利拉鲁肽(100-1000 nM)能够抑制细胞因子和游离脂肪酸诱导的凋亡,分别超过95%和50%,这一效应会被GLP-1受体拮抗剂exendin-3 (9-39)和PI3K抑制剂渥曼青霉素所阻断[2]。补充膳食诱导的大鼠肥胖模型中,利拉鲁肽(0.2mg/kg,皮下注射,一天两次)降低卡路里摄取,改变饮食偏好到更高的食物与糖果比例,逆转体重和脂肪增加,以及增高胰岛素敏感性[3]。含利拉鲁肽的配方可用作辅助药物来治疗II型糖尿病,以及用于超重或肥胖成人的慢性体重控制。
产品特性 1) CAS NO:204656-20-2 2) 化学名:L-histidyl-L-alanyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl- L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-N6-[N-(1-oxohexadecyl)-L-γ-glutamyl]-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginyl-glycine 3) 序列:H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(γ -Glu- palmitoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg- Gly-Arg-Gly-OH 4) 同义名:Victoza, Liraglutida, Liraglutidum, NN 2211, NN-2211 5) 分子式:C172H265N43O51 6) 分子量:3751.2 7) 纯度:≥98% 8) 外观:白色至类白色粉末 9) 溶解性:溶于稀氨水、溶于水(1mg/ml)
保存与运输方法 保存:-20℃避光干燥保存,至少2年有效。 运输:冰袋运输。
注意事项 1) 针对溶解性比较差的化合物,可通过37℃孵育以及超声的方式来促进其溶解。 2) 本品并非商业化的临床药物,仅用作科研用途,不得用作临床诊断或治疗,不得用于食品或药品,绝对禁止用在人身上。 3) 为了您的安全和健康,请穿实验服并戴一次性手套操作。
配制储存液
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文献1,Raun K et al. Liraglutide, a Long-Acting Glucagon-Like Peptide-1 Analog, Reduces Body Weight and Food Intake in Obese Candy-Fed Rats, Whereas a Dipeptidyl Peptidase-IV Inhibitor, Vildagliptin, Does Not. Diabetes. 2007 Jan;56(1):8-15. PMID: 17192459 体内研究: 动物模型(Animal Model):Sprague-Dawley female rats 给药剂量(Dosages):After the initial 12 weeks, the candy-fed (DIO) rats were further randomized into treatment groups for another 12 weeks: 1) liraglutide 0.2 mg/kg s.c. twice daily (n = 10), 2) vildagliptin 10 mg/kg twice daily orally (n = 10), 3) control vehicle twice daily subcutaneously (n = 7), 4) control vehicle twice daily orally (n = 7), and 5) DIO-Chow (candy excluded from diet, reverting to chow only) plus vehicle twice daily orally (n = 10). |
文献2,Abdulreda MH et al.Liraglutide Compromises Pancreatic β Cell Function in a Humanized Mouse Model. Cell Metab. 2016 Mar 8;23(3):541-6. PMID: 26876561 体内研究: 动物模型(Animal Model):Human islets transplanted into the anterior chamber of the eye of streptozotocin (STZ)-induced diabetic nude mice. 药物配制(Preparation):A 1000x stock solution was prepared by dissolving 18 mg in 1 ml of sterile normal saline solution (0.9% sodium chloride), divided in single-use aliquots, and stored at−20°C. 注射剂量(Dosages):Nonfasting glycemia before and ~35 days after human islet intraocular transplantation in diabetic nude mice treated with liraglutide (300 μg/kg/day s.c.) or saline (control). Daily liraglutide or saline treatments were started two days prior to transplantation (n = 14 mice/treatment). |
[1] Knudsen LB et al.Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration. J Med Chem. 2000 May 4;43(9):1664-9.
[2] Bregenholt S et al. The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits beta-cell apoptosis in vitro. Biochem Biophys Res Commun. 2005 May 6;330(2):577-84.
[3] Raun K et al. Liraglutide, a Long-Acting Glucagon-Like Peptide-1 Analog, Reduces Body Weight and Food Intake in Obese Candy-Fed Rats, Whereas a Dipeptidyl Peptidase-IV Inhibitor, Vildagliptin, Does Not. Diabetes. 2007 Jan;56(1):8-15.
— —Written/Edited by V. Shallan【版权归MKBio懋康所有】
上海懋康生物科技有限公司是一家涉足于生命科学和生物技术领域研究的试剂、仪器和实验室消耗品与实验服务工作,主要从事细胞生物学、植物学、分子生物学、免疫学、生物化学、蛋白组学。生物制药与诊断试剂研发生产等领域。 本公司秉承“以人为本,以诚为信、合同守信”的经营理念。坚持"品质保障"的原则为广大客户提供优质产品。