| 目录号 | MZ95033-1G | 售价 | 360.00元 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 规格 | 1g | 运输温度 | 室温 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 其他名称 | 4-(Oxan-2-yloxy)phenol | 保存温度 | -20ºC干燥保存 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CAS号 | 53936-56-4 | 有效期 | 2年 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 应用 | 酪氨酸酶抑制剂，黑色素生成抑制剂 | 订购数量 |
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产品简介: Deoxyarbutin 脱氧熊果苷
产品标签 Deoxyarbutin 脱氧熊果苷；β-Arbutin β-熊果苷；Tyrosinase inhibitor 酪氨酸酶抑制剂；Melanin production inhibitor 黑色素生成抑制剂；Polyphenol Oxidase 蘑菇多酚氧化酶；CAS：53936-56-4；
产品信息
产品描述 脱氧熊果苷（Deoxyarbutin，CAS：53936-56-4）是一种有效且可逆的酪氨酸酶抑制剂（IC50=50nM）。能抑制黑色素合成，引起明显和长期的皮肤增白效果。
产品特性 1） CAS NO：53936-56-4 2） 化学名：4-(Oxan-2-yloxy)phenol 3） 分子式：C11H14O3 4） 分子量：194.23 5） 纯度：≥99% 6） 外观：白色或类白色粉末 7） 溶解性：溶于DMSO（100mM）、乙醇（100mM）、不溶于水
8）
化学结构图：
保存与运输方法 保存：-20ºC干燥保存，至少2年有效。 运输：室温运输
注意事项 1） 本品不是临床药物，只能用于科研用途，不能用于诊断或临床用途。 2） 为了您的安全和健康，请穿实验服并戴一次性手套操作。
配制储存液
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文献1，Boissy RE et al.DeoxyArbutin: A novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency.Exp Dermatol. 2005 Aug;14(8):601-8. PMID: 16026582 体内研究（动物）： 动物模型（Animal Model）：Hairless pigmented (black) guinea pig models 药物配制（Preparation）：dA (DeoxyArbutin) was prepared in I base cream consisting of water (25%), 0.2M triethanolamine hydrochloride (44.5%), glycerin (3.75%), Parson MCX (7.5%), cutina GMS (2.5%), and tegin 90 (2.5%). 实验方法（Assay）：For experiments comparing skin lightening effects of test compounds, skin was treated daily for 9 weeks with dA, Hydroquinone (HQ), kojic acid and arbutin (3%) in I base cream. Ten animals were in each treatment group, and three independent experiments were performed. Skin lightness was measured at baseline and then weekly with a colorimeter. 实验结果（Results）：Both dA and HQ resulted in skin lightening during the initial 3 weeks of treatment, the extent of dA-induced skin lightening plateaued while the HQ-treated skin darkened and returned to the pretreatment value. The dA treated sites showed no signs of skin irritation. In contrast, HQ treated skin showed signs of irritation that resulted in irregular darkening, beginning at 3 weeks of treatment. In contrast, kojic acid, and arbutin were not significantly different from the vehicle control. |
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文献2，Chawla S et al. Mechanism of tyrosinase inhibition by deoxyArbutin and its second-generation derivatives.. Br J Dermatol. 2008 Dec;159(6):1267-74. PMID:18811684 体内研究（细胞）： 细胞类型（Cell type）：Human melanocytes 药物配制（Preparation）：All compounds (dA, dF, fdA, tdA and HQ) were dissolved in sterile DMSO. Stock solutions of compounds were prepared and protected from light at -20℃until use. At time of use, compounds were further diluted in growth medium to produce the final required concentration. Compounds were tested at the appropriate concentration range (1-100μM) in triplicate in order to calculate LD50values. 实验方法（Assay）：Melanocytes were seeded at 1-3×105cells and allowed to grow for 48h before treatment. Cultured were treated daily with fresh growth media containing test compound for 5 days. On the sixth day, cells were detached and counted. 实验结果（Results）：A concentration-dependent decrease in the cell number of both was observed for all inhibitors (dA, dF, fdA, tdA and HQ). LD50concentrations of dA and its derivatives are listed below.
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相关产品
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货号 |
名称 |
规格 |
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MZ95031-5G |
Arbutin 熊果苷 |
5g |
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MZ95032-1G |
alpha-Arbutin alpha-熊果苷 |
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MZ95033-1G |
Deoxyarbutin 脱氧熊果苷 |
1g |
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25KU |
— —Written/Edited by V. Shallan【版权归MKBio懋康所有】
上海懋康生物科技有限公司是一家涉足于生命科学和生物技术领域研究的试剂、仪器和实验室消耗品与实验服务工作，主要从事细胞生物学、植物学、分子生物学、免疫学、生物化学、蛋白组学。生物制药与诊断试剂研发生产等领域。 本公司秉承“以人为本，以诚为信、合同守信”的经营理念。坚持"品质保障"的原则为广大客户提供优质产品。
