产品简介:
Decylubiquinone
癸基泛醌
产品标签
Decylubiquinone癸基泛醌；米酵菌酸（Bongkrekic Acid, BA）；Coenzyme Q10辅酶Q10；Mitochondrial permeability transition pore (MPTP)；活性氧生成抑制剂ROSproduction inhibitor；CAS：55486-00-5；
产品信息
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产品名称
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产品编号
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规格
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价格（元）
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Decylubiquinone癸基泛醌
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MX3266-5MG
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5mg
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523
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Decylubiquinone癸基泛醌
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MX3266-10MG
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10mg
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993
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Decylubiquinone癸基泛醌
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MX3266-50MG
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50mg
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4093
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产品描述
癸基泛醌（Decylubiquinone）是泛醌（辅酶Q10）的结构类似物。能够阻断谷胱甘肽耗竭应激引起的活性氧（ROS）生成，以及抑制线粒体膜通透性转换的活化。癸基泛醌能抑制Ca2+依赖性的线粒体膜通透性转化孔（MPTP）的开放，不会干扰呼吸作用。L929细胞内，通过抑制细胞色素c的释放，癸基泛醌（5μM）抑制依托泊苷（MX3256-100MG）诱导的凋亡。在发育和心血管功能研究的斑马鱼模型中，延缓鱼藤酮诱导的心功能障碍。能用作各种醌氧化还原酶的底物。
产品特性
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化学名：2-Decyl-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
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CAS NO：55486-00-5
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同义名：2,3-Dmdb
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分子式：C19H30O4
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分子量：322.44
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纯度：≥98%
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外观：乙醇溶液（浓度见标签）
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化学结构式：
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保存与运输方法
保存：-20℃干燥保存，2年有效。
运输：室温运输。
注意事项
1） 本品并非商业化的临床药物，仅用作科研用途，不得用作临床诊断或治疗，不得用于食品或药品，绝对禁止用在人身上。
2） 为了您的安全和健康，请穿实验服并戴一次性手套操作。
使用方法【源自文献，仅作参考】
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文献1，Telford JE, Kilbride SM, Davey GP. Decylubiquinone increases mitochondrial function in synaptosomes. J Biol Chem. 2010 Mar 19;285(12):8639-45. doi: 10.1074/jbc.M109.079780. Epub 2010 Jan 14. PMID: 20080966; PMCID: PMC2838286.
体外研究（In Vitro Assay）：
样本类型（Sample type）：Synaptosomes
实验方法（ETC Assays）： The stored synaptosomal samples were freeze-fractured three times by rapid freezing in liquid nitrogen followed by thawing at 37 °C in a water bath. The complex activities of the samples were determined on a Cary UV spectrophotometer at 37 °C. Reaction buffer (10 mm MgCl2 and 25 mm potassium phosphate, pH 7.2), 0.2 mm NADH, 2.5 mg of bovine serum albumin, 1 mm KCN, and 100 μg of synaptosomes were added to plastic cuvettes with a final volume of 1 ml. Decylubiquinone (50 μM) was used to initiate the reaction, and the rates were recorded for 7–8 min. To determine the rotenone-insensitive rates, rotenone (10 μm) was added to the cuvettes, and the rates were monitored for a further 5–6 min.
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文献2，Li J, Zheng S, Cheng T, Li Y, Mai X, Jiang G, Yang Y, Zhang Q, Li J, Zheng L, Wang L, Qi C. Decylubiquinone Inhibits Colorectal Cancer Growth Through Upregulating Sirtuin2. Front Pharmacol. 2022 Feb 1;12:804265. doi: 10.3389/fphar.2021.804265. PMID: 35177983; PMCID: PMC8844026.
体外研究（In Vitro Assay）：
细胞类型（Cell type）： CRC cells (HCT116 and LoVo cells)
实验方法（Cell viabilityassay）： CRC cells (1.0×103cells/well) were seeded in 96-well plates andtreated with different concentrations of Dub (0, 15, 30, 45, 60, 75, 90, 105 μM), and control cells were treated with DMSO. After 96 h of DUb treatment, MTT was added to measure cell viability. Half maximal inhibitory concentration (IC50) values were calculated from the inhibitory curves. The IC50 values of DUb were calculated to be 45.84 µM for HCT116 cells and 28.11 µM for LoVo cells.
体内研究（In Vivo Assay）：
动物模型（Animal Model）：6-week-old athymic nude mice
实验方法（Assay）：Athymic nude mice were intraperitoneally treatedwith DUb (5 mg/kg, three times per week for 3 weeks) or DMSO for 54 days.CT26 CRC cell line was injected subcutaneously into the flanks of 6-8-week-old BALB/c mice. CT26 xenograft mice were treated intraperitoneally with DUb (5 mg/kg) or DMSO every day since the tumor could be observed with the naked eye for 12 days. The body weights of mice were weighed during DUb or DMSO treatment.
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— —Written/Edited by V. Shallan【版权归MKBio懋康所有】
上海懋康生物科技有限公司是一家涉足于生命科学和生物技术领域研究的试剂、仪器和实验室消耗品与实验服务工作，主要从事细胞生物学、植物学、分子生物学、免疫学、生物化学、蛋白组学。生物制药与诊断试剂研发生产等领域。 本公司秉承“以人为本，以诚为信、合同守信”的经营理念。坚持"品质保障"的原则为广大客户提供优质产品。
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