产品简介:
Berberine
Chloride 盐酸小檗碱(盐酸黄连素)
产品信息
产品名称
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产品编号
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规格
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价格(元)
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Berberine Chloride 盐酸小檗碱(盐酸黄连素)
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MS2002-20MG
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20mg
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220
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Berberine Chloride 盐酸小檗碱(盐酸黄连素)
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MS2002-100MG
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100mg
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600
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产品描述
小檗碱(Berberine)是来源于毛茛科药用植物黄连的一种异喹啉类生物碱,具有非常多样的药理作用,包括1)抗肿瘤效应,包括乳腺癌、白血病、黑素瘤、鳞状细胞癌、胰腺癌、肝癌等;2)一种有效的口服降血糖剂,对脂质代谢起到积极效果;3)一种中药抗抑郁剂,一种阻止神经退行性紊乱的神经保护剂;4)减少非酒精性脂肪性肝病(NAFLD)大鼠的肝脂肪含量,也能防止肝星状细胞(HSCs)增殖,HSCs在肝损伤中纤维化发展很关键;5)体外改善促炎症细胞因子诱导的肠道上皮紧密连接损伤,可能是一种靶向诊治药物能够复原肠道疾病状态中的屏障功能;6)可能是一种广谱的抗微生物制剂;另外,小檗碱在紫外光照下发荧光,组织学研究中通常用于肥大细胞颗粒内的肝素染色。
本品是盐酸形式的小檗碱,即盐酸小檗碱(Berberine
chloride or Berberine hydrochloride),又称为盐酸黄连素,CAS NO. 633-65-8,以冻干粉形式提供,纯度>98%。
产品特性
1) CAS NO:633-65-8
2) 化学名:9,10-dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium
chloride; 5,6- Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium
Chloride; 7,8,13,13a-Tetradehydro- 9,10-dimethoxy-2,3-(methylenedioxy)berbinium
Chloride;
3) 同义名:Berberine
hydrochloride 盐酸小孽碱,盐酸小孽碱;盐酸黄连素;黄连素盐酸盐;氯化黄连素;Umbellatine;Natural
Yellow 18 自然黄18;
4) 分子式:C20H18NO4Cl
5)
分子量:371.81
6)
含量:>98%
7)
外观:浅黄色至黄色结晶性粉末
8)
溶解性:溶于DMSO(40mg/ml,25℃),甲醇、乙醇(<1mg/ml,25℃),H2O(<1mg/ml,25℃)
9)
化学结构:
保存与运输方法
保存:2-8ºC干燥保存,或置于-20℃长期保存,至少2年有效。
运输:常温运输。
产品应用【来自文献,仅做参考】
文献1,Lee
YS et al.Berberine, a natural plant product,
activates AMP-activated protein kinase with beneficial metabolic effects in
diabetic and insulin-resistant states.Diabetes. 2006 Aug;55(8):2256-64. PMID: 16873688
体内研究:
实验目的(Purpose): Berberine has antidiabetic properties, although its
mode of action is unknown. Here, we have investigated the metabolic effects
of Berberine in two animal models of insulin resistance and in insulin- responsive
cell lines.
动物模型I(Animal Model I):Obese and diabetic C57BLKS/J-Leprdb/Leprdbmale mice
实验方法I(Assay I):From 12
weeks of age, berberine was injected intraperitoneally (5 mg · kg body wt−1·
day−1) into the
mice for 26 days.
动物模型II(Animal Model II):Wistar rats (250 g)were
acclimatized in communal cages at 22°C, with a 12-h light 12-h dark cycle
(lights on at 0600) for 1 week and had access to a standard chow diet and
water ad libitum. Rats
were then randomly assigned to receive either the standard chow diet as the
control group (CH group) or a high-fat (60% calories as saturated fat) diet
for 4 weeks.
实验方法II(Assay II):After 2 weeks of feeding, rats were randomly assigned to
receive oral administration of either vehicle (0.5% methylcellulose) or
berberine (380 mg · kg−1· day−1) by gavage
for the last 2 weeks.
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文献2,Zhu Y et al. Berberine induces apoptosis and DNA damage in
MG-63 human osteosarcoma cells.Mol Med Rep. 2014 Oct;10(4):1734-8. PMID:
25050485
体外研究:
实验目的(Purpose):To investigate the cytotoxic effect of berberine on
MG-63 cells
细胞类型(Cell type):MG-63 human osteosarcoma cell line (wild type)
药物配制(Preparation):Berberine was dissolved in dimethyl sulfoxide (DMSO)
实验方法(Assay):MG-63 cells were seeded at a density of 1×104cells/well in 100 μl of cell culture medium and then placed in a 96-well plate.
Following 12 h of incubation, the cells were treated with 0, 20, 40, 80 μM
berberine for 12 and 24 h. MTT was used to detect cell cytotoxicity.
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文献3,Chu
SC et al.Berberine reverses
epithelial-to-mesenchymal transition and inhibits metastasis and
tumor-induced angiogenesis in human cervical cancer cells. Mol Pharmacol.
2014 Dec;86(6):609-23. PMID: 25217495
体内研究:
实验目的(Purpose):To study the in vivo antitumor effects of berberine
动物模型I(Animal Model I):After subcutaneous implantation of SiHa cells, BALB/c nude
mice (n = 5 for each group) were treated with placebo or berberine and then
analyzed for tumor growth.
实验方法I(Assay I):The mice
were randomly divided into three groups (n = 5 for each group) and fed by
oral gavage with placebo (control) and berberine (10 and 20 mg/kg per day).
给药途径(Administration):Oral gavage
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注意事项
1)
本品并非商业化药物,不可用作临床或诊断用途,仅限科研使用。
2)
为了您的安全和健康,请穿实验服并戴一次性手套操作。
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— —Written/Edited by V. Shallan【版权归MKBio懋康所有】
上海懋康生物科技有限公司是一家涉足于生命科学和生物技术领域研究的试剂、仪器和实验室消耗品与实验服务工作,主要从事细胞生物学、植物学、分子生物学、免疫学、生物化学、蛋白组学。生物制药与诊断试剂研发生产等领域。 本公司秉承“以人为本,以诚为信、合同守信”的经营理念。坚持"品质保障"的原则为广大客户提供优质产品。
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