产品简介:
Mycophenolic
Acid (MPA) 霉酚酸（麦可酚酸）
产品标签
Mycophenolic Acid (MPA) 霉酚酸；Immunosuppressive Drug 免疫抑制剂；Inosine
monophosphatase dehydrogenase次黄嘌呤单核苷酸脱氢酶；IMPDH Inhibitor; Mycophenolate
mofetil 吗替麦考酚酯；CAS NO：24280-93-1；
产品信息
|
产品名称
|
产品编号
|
CAS NO.
|
规格
|
价格（元）
|
|
Mycophenolic Acid (MPA) 霉酚酸（麦可酚酸）
|
MZ9231-0100MG
|
24280-93-1
|
100mg
|
298
|
|
Mycophenolic
Acid (MPA) 霉酚酸（麦可酚酸）
|
MZ9231-1000MG
|
24280-93-1
|
1g
|
1178
|
产品描述
霉酚酸（Mycophenolic Acid，MPA），又名麦可酚酸，是一种免疫抑制剂，用来预防器官移植后的排斥反应。MPA的功能在其是一种有效且可逆的次黄嘌呤单核苷酸脱氢酶（IMPDH）抑制剂，淋巴细胞中能阻断GTP的从头合成并引起RNA和DNA合成的减少，从而防止淋巴细胞增殖和活化，并抑制抗体生成。MPA还具有抗真菌、抗细菌、抗病毒和抗肿瘤效应。
产品特性
1）CAS NO：24280-93-1
2）化学名：6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic
acid
3）同义名：MPA;NSC 129185;
4）分子式：C17H20O6
5）分子量：320.34
6）纯度：≥98%
7）外观：白色或类白色粉末
8）溶解性：溶于乙醇、甲醇、DMSO（30mg/ml）、不溶于水
9）化学结构图：
保存与运输方法
保存：2-8ºC干燥保存，或置于-20ºC长期干燥保存，至少2年有效。
运输：室温运输。
注意事项
1）本霉酚酸（MPA）不是临床药物，只能用于科研用途，不能用于诊断或临床用途。
2）为了您的安全和健康，请穿实验服并戴一次性手套操作。
使用方法【源自文献，仅作参考】
|
文献1，Azzarone A et al. Effects on in vivo and in vitro hepatocyte
proliferation of methylprednisolone, azathioprine, mycophenolic acid,
mizoribine, and prostaglandin E1. Transplant Proc. 1992 Dec;24(6):2868-71. PMID:
1465977
体外研究：
细胞类型（Cell type）：Hepatocytes (from rat liver) in Primary Culture
药物配制（Preparation）：MPA was dissolved in DMSO
实验方法（Assay）：MPA was dissolved in DMSO and added in the appropriate
concentrations (0.6, 1.2, 2.4, 5, 10 μg/ml). The amount of DMSO added to the
medium was never more than 2 μL/mL, which does not affect hepatocyte
proliferation. The in vitro DNA synthesis was detected by [3H] Thymidine
Incorporation.
体内研究：
动物模型（Animal Model）：70% partial hepatectomy rat
model
药物配制（Preparation）：MPA was dissolved in 0.5% carbossil-methil-cellulose (CMC),
0.4% Tween, and 0.9% alcohol in saline.
注射剂量（Dosages）：Rats were assigned to groups and treated for 4 days as
controls or with MPA (15mg/kg).On the 4th day,
between 0900 and 1030 hours, the rats received a standard 70% hepatectomy
under light ether anesthesia. Food and drink were allowed immediately. Twenty-four
hours after the hepatectomies, 185 × 10−4Bq [3H] thymidine was administered to all rats by
intraperitoneal injection.
给药途径（Administration）：Oral (p.o.)
|
|
文献2，Sugiyama K et al. Peripheral Lymphocyte Response to
Mycophenolic Acid In Vitro and Incidence of Cytomegalovirus Infection in
Renal Transplantation. Cell Med. 2013 Oct 23;6(1-2):47-55. PMID: 26858880
体外研究：
细胞类型（Cell type）：PBMCs
药物配制（Preparation）：MPA was dissolved in Ethanol
实验方法（Assay）：PBMCs was placed into each well of a 96-well flat-bottomed
microplate.Saline
containing concanavalin A was added to each well to a final mitogen
concentration of 5.0 µg/ml. Subsequently, an ethanol solution containing MPA
was added to give a final drug concentration of 0.001, 0.01, 0.1, 1, 10, 100,
1,000, or 10,000 ng/ml. The same volume of each vehicle solution was added to
the control wells (no concanavalin A or MPA treatment). After 4 days of culture,
MTT assay was done.
|
相关产品
— —Written/Edited by V.
Shallan【版权归MKBio懋康所有】
上海懋康生物科技有限公司是一家涉足于生命科学和生物技术领域研究的试剂、仪器和实验室消耗品与实验服务工作，主要从事细胞生物学、植物学、分子生物学、免疫学、生物化学、蛋白组学。生物制药与诊断试剂研发生产等领域。 本公司秉承“以人为本，以诚为信、合同守信”的经营理念。坚持"品质保障"的原则为广大客户提供优质产品。
|
