产品简介:
(-)-Epigallocatechin
Gallate (EGCG)
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产品信息
产品名称
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产品编号
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CAS NO.
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规格
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价格(元)
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(-)-Epigallocatechin
Gallate (EGCG) (-)-表没食子儿茶素没食子酸酯
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MZ3651-20MG
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989-51-5
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20mg
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238
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(-)-Epigallocatechin Gallate (EGCG) (-)-表没食子儿茶素没食子酸酯
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MZ3651-100MG
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989-51-5
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100mg
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598
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(-)-Epigallocatechin Gallate (EGCG) (-)-表没食子儿茶素没食子酸酯
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MZ3651-500MG
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989-51-5
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500mg
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2188
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【温馨提示】:见我司的小分子化合物常见问题-懋康生物。
产品描述
(-)-表没食子儿茶素没食子酸酯((-)-Epigallocatechin
Gallate, EGCG),CAS NO. 989-51-5,是从绿茶中提取纯化的一种成分,是儿茶素类化合物中最有效的活性成分,具有最强的抗氧化、抗癌、抗突变和抗血管生成活性,已被用于多种肿瘤包括肝癌、胃癌、皮肤癌、乳腺癌和结肠癌等的化学预防研究中,也对许多病毒包括HCV、HIV-1、HSV-1、HSV-2、腺病毒等有抑制作用。EGCG属于一种天然的多酚黄酮类抗生素,能够抑制端粒酶(telomerase)和DNA甲基转移酶(DNA methyltransferase),阻止EGF受体和HER-2受体的激活,也能抑制脂肪酸合成酶和谷氨酸脱氢酶的活性。是一种β-分泌酶抑制剂(IC50=1.6μM),能抑制淀粉样蛋白的组装,抑制由蛋白如Aβ,α-突触核蛋白和亨廷顿蛋白介导的淀粉样纤维的形成。能抑制细胞生长和选择性诱导A431和人胰腺癌细胞的凋亡。也是DNMT1抑制剂。
产品特性
1) CAS NO:989-51-5
2) 化学名:3,4,5-Trihydroxybenzoic acid
(2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1- benzopyran-3-yl
ester
3) 同义名:Epigallocatechin gallate表没食子儿茶素没食子酸酯;Tea catechin儿茶素;NVP-XAA723;Teavigo;
4) 分子式:C22H18O11
5)分子量:458.37 g/mol
6)纯度:≥98% (HPLC)
7) 外观:类白色至白色粉末
8)溶解性:溶于H2O(5 mg/ml),DMSO(20 mg/ml),无水乙醇(45 mg/ml)
9)化学结构:
保存与运输方法
保存:-20ºC干燥保存,3年有效。
运输:常温运输。
使用方法【源自文献,仅作参考】
文献1,Rasheed
NO et al.Nephro-toxic effects of
intraperitoneally injected EGCG in diabetic mice: involvement of oxidative
stress, inflammation and apoptosis. Sci Rep. 2017 Jan 18;7:40617. PMID:
28098182
体内研究:
动物模型(Animal Model):Male Swiss albino mice weighing 25–30 g
药物配制(Preparation):Teavigo, a highly purified extract containing 94% EGCG,
dissolved in saline
注射剂量(Dosages):Mice were randomly divided into 4 groups
8 mice each except group 4 in which 15 mice were used: Group 1 received
saline served as normal control. Group 2 received a single dose of STZ
(150 mg/kg, i.p) used as diabetic control.Group
3 received EGCG (100 mg/kg, i.p) dissolved in saline for 4 days. Group
4 received STZ as in group 2 then the diabetic animals were injected after
48 hrs with EGCG as in group 3. After 48 hrs of STZ injection, animals with
blood glucose level ≥200 mg/dl were selected as diabetic animals.
给药途径(Administration):Intraperitoneal (i.p.) injection
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文献2,Pan C et al.NRF2 Plays a Critical Role in Both Self and EGCG Protection against Diabetic Testicular Damage. Oxid Med Cell Longev. 2017;2017:3172692. PMID: 28698767
体内研究:
动物模型(Animal Model):Eight-week-old male mice that was successfully induced as diabetic
mice.
药物配制(Preparation):EGCG dissolved in normal saline
注射剂量(Dosages):The diabetic mice and age-matched
controls were treated daily by subcutaneously injected EGCG (100 mg/kg≥98%, dissolved in normal saline) or normal saline daily, for a total
period of 24 weeks. Blood glucose was recorded on days 0, 28, 56, 84, 112,
140, and 168, after diabetes onset.
给药途径(Administration):Subcutaneous (s.c.) injection
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注意事项
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