产品名称

产品编号

CAS NO.

规格

价格（元）

促销价（元）

Semaglutide索马鲁肽

MZ7352-1MG

910463-68-2

1mg

1580

1422

Semaglutide索马鲁肽

MZ7352-5MG

910463-68-2

5mg

3980

3582

Semaglutide索马鲁肽

MZ7352-10MG

910463-68-2

10mg

5980

5382

          质量

溶剂体积

浓度

1mg

5mg

10mg

0.5mM

0.4862 mL

2.4310 mL

4.8619 mL

0.1mM

2.4310 mL

12.1549 mL

24.3097mL

文献1，Rakipovski G, Rolin B, Nøhr J, Klewe I, Frederiksen KS, Augustin R, Hecksher-Sørensen J, Ingvorsen C, Polex-Wolf J, Knudsen LB. The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE-/- and LDLr-/- Mice by a Mechanism That Includes Inflammatory Pathways. JACC Basic Transl Sci. 2018 Nov 21;3(6):844-857. doi: 10.1016/j.jacbts.2018.09.004. PMID: 30623143; PMCID: PMC6314963.

体内研究（动物模型）：

动物模型（Animal Model）：C57BL/6J lean male mice at 12 weeks of age

实验方法（Assay）：To studyacute inflammation in vivo study design, C57BL/6J lean male mice at 12 weeks of age were givenSC doses of semaglutide (60.0 μg/kg) or vehicle control 1 hour prior to receiving an IP dose of lipopolysaccharide (LPS) (0.05 mg/kg, Escherichia coli O55:B5) or vehicle control.Blood samples were collected from the sinus orbital vein at 1 and 4 h after LPS dose.

文献2，Wang L, Ding J, Zhu C, Guo B, Yang W, He W, Li X, Wang Y, Li W, Wang F, Wang F, et al: Semaglutide attenuates seizure severity and ameliorates cognitive dysfunction by blocking the NLR family pyrin domain containing 3 inflammasome in pentylenetetrazole‑kindled mice. Int J Mol Med 48: 219, 2021

体外研究：

细胞类型（Cell type）：BV2 cells

实验方法（Assay）： BV2 cells were seeded into 96-well plates (1×104 cells/well) for 12 h, and thentreated with different doses (300, 600, 900 or 1,000 nM) of semaglutide for 20 h at 37°C. A blank well with culture medium was used to detect background, and five replicate wells were established per group. CCK-8 reagent (100 µl) was added toevaluate cellular proliferation.

体内研究（动物模型）：

动物模型（Animal Model）：C57BL/6J mice (male, 10±2 weeks old; weight, 25±3 g)

实验方法（Assay）：The animals were randomized into five groups (20 per group), all of which were treated by intraperitoneal (i.p.) injection. In the control group (1% DMSO, i.p.), mice received 20 injections in total - 19 injections every other day for 37 days, and a final injection on the 45th day.For the semaglutide group [25 nM/kg semaglutide i.p.], the administration schedule was the same as that for the control group. In the PTZ group [37 mg/kg PTZ, i.p.], the mice received a total of 16 injections - one injection every other day from the 9th to the 37th day for a total of 15 injections, and a final injection on the 45th day.For the low-dose semaglutide group [37 mg/kg PTZ + 10 nM/kg semaglutide, i.p.], the semaglutide administration schedule was the same as that for the control group, and the PTZ administration schedule was the same as that for the PTZ group, 30 min after each injection of semaglutide.For the high-dose semaglutide group (37 mg/kg PTZ + 25 nM/kg semaglutide, i.p.), the administration schedule was the same as that for the low-dose semaglutide group.

货号

名称

规格

MZ7351-1MG

Liraglutide利拉鲁肽

1mg

MZ7352-1MG

Semaglutide索马鲁肽

1mg

MZ3403-1G

Metformin Hydrochloride盐酸二甲双胍

1g

MZ99023-1G

Acarbose阿卡波糖

1g

MS1601-100MG

Streptozotocin (STZ)链脲佐菌素

100mg