| 目录号 | MZ6402-100MG | 售价 | 1592.00元 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 规格 | 100mg | 运输温度 | 冰袋运输。 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 其他名称 | 保存温度 | -20ºC避光干燥保存，至少2年有效。 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CAS号 | 36913-39-0 | 有效期 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 应用 | 订购数量 |
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产品简介: MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide)
产品标签 MPP+ iodide；MPTP；帕金森病动物模型；Ferroptosisinhibitor；Necrostatin-1；Ferrostatin-1 (Fer-1)；CAS：36913-39-0；
产品信息：
产品描述 MPP+iodide (N-Methyl-4-Phenylpyridinium Iodide)是神经毒素MPTP的活性代谢物，在帕金森病动物模型中选择性破坏多巴胺能神经元。MPP+主要通过抑制线粒体电子传递链复合物I，引起ATP耗竭和氧化应激增高，从而诱导神经毒性。MPP+诱导Necrostatin-1 (Nec-1)和 Ferrostatin-1 (Fer-1)敏感的SH-SY5Y细胞坏死，但MPP+诱导的坏死性细胞死亡与铁坏死是不同的生理过程。
产品特性 1） 化学名：1-Methyl-4-phenylpyridin-1-ium iodide 2） 同义名：N-Methyl-4-Phenylpyridinium Iodide; 1-methyl-4-phenyl-pyridinium, monoiodide; MPP+;N-甲基-4-苯基吡啶鎓碘化物；1-甲基-4-苯基-吡啶鎓碘化物；1-甲基-4-苯基吡啶碘化物； 3） CAS NO：36913-39-0 4） 分子式：C12H12IN 5） 分子量：297.16） 纯度：≥98%7） 外观：固体8） 溶解性：溶于H2O（100mM）
9） 化学结构式：
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浓度 |
1mg |
5mg |
10mg |
|
1mM |
3.3654 mL |
16.8271 mL |
33.6542mL |
|
5mM |
0.6731mL |
3.3654 mL |
6.7308mL |
|
10mM |
0.3365 mL |
1.6827 mL |
3.3654 mL |
|
文献1，Stahl K, Rahmani S, Prydz A, Skauli N, MacAulay N, Mylonakou MN, Torp R, Skare Ø, Berg T, Leergaard TB, Paulsen RE, Ottersen OP, Amiry-Moghaddam M. Targeted deletion of the aquaglyceroporin AQP9 is protective in a mouse model of Parkinson's disease. PLoS One. 2018 Mar 22;13(3):e0194896. doi: 10.1371/journal.pone.0194896. PMID: 29566083; PMCID: PMC5864064. 体内研究（动物模型）： 动物模型（Animal Model）：C57BL/6J WT and Aqp9-/- mice 配制方法（Formulation）：MPP+ (7.5 μg dissolved in saline) 实验方法（Assay）：C57BL/6J WT (n = 34) and Aqp9-/- mice (n = 29) were deeply anesthetized with zoletil mixture, Rompunand Fentanyl and then subjected tostereotaxic intrastriatal injections of MPP+ (7.5 μg dissolved in saline) or saline. 1 μl MPP+ solution or saline was injected into the striatum 0.6 mm anterior to Bregma, 2.2 mm laterally and 3.2 mm ventrally at 12 μl/hr using a syringe pump. MPP+ was protected against light during the procedure. The injector was left for 5 minutes to allow diffusion before suture. |
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文献2，Xu J, Gao X, Yang C, Chen L, Chen Z. Resolvin D1 Attenuates Mpp+-Induced Parkinson Disease via Inhibiting Inflammation in PC12 Cells. Med Sci Monit. 2017 Jun 2;23:2684-2691. doi: 10.12659/msm.901995. PMID: 28572562; PMCID: PMC5465971. 体外研究（细胞实验）： 细胞类型（Cell types）：PC12 cells 实验方法（Assay）：The in vitro PD model was established by treatment of PC12 cells with250 μM MPP+ for approximately 24 hours.Different concentrations of RvD1 (50, 100, 200 nM) were administrated two hours prior to MPP+ treatment, afterwards, PC12 cells were used for following experiments. |
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文献3，Christensen C, Þorsteinsson H, Maier VH, Karlsson KÆ. Multi-parameter Behavioral Phenotyping of the MPP+ Model of Parkinson's Disease in Zebrafish. Front Behav Neurosci. 2020 Dec 18;14:623924. doi: 10.3389/fnbeh.2020.623924. PMID: 33390914; PMCID: PMC7775599. 体内研究（动物模型）： 动物模型（Animal Model）：Zebrafish larvae 配制方法（Formulation）：Both MPP+ and PBA were dissolved in the system water. 实验方法（Assay）：Zebrafish larvae were incubated between 1 and 5 dpf in the presence or absence of 500 μM MPP+ at a total volume of 25 ml system water. The drug solutions were freshly prepared and replaced between 11:00 and 12:00 am at 2, 3, and 4 dpf.Deceased larvae were removed daily, but no differences in mortality were observed between MPP+ exposed larvae and untreated larvae. |
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— —Written/Edited by V. Shallan【版权归MKBio懋康所有】
上海懋康生物科技有限公司是一家涉足于生命科学和生物技术领域研究的试剂、仪器和实验室消耗品与实验服务工作，主要从事细胞生物学、植物学、分子生物学、免疫学、生物化学、蛋白组学。生物制药与诊断试剂研发生产等领域。 本公司秉承“以人为本，以诚为信、合同守信”的经营理念。坚持"品质保障"的原则为广大客户提供优质产品。
